The immune system in human body is a complex network working in the body. The immune system refers to all parts of the body that works to defend it against harmful enemies. In people with immunological fertility issue there body identifies the part of the reproductive job as an enemy and sends natural killers cells to attack. Whereas a normal immune reaction would only identify an enemy like foreign invaders such as virus, parasite and bacteria’s.
Who needs immunological fertility testing?
- IVF failure
- 3 miscarriage before the age of 35
- Poor egg production from stimulated cycle
- Blighted ovum
- Pre-existing immune problems
- unexplained infertility diagnosis
- previous pregnancies showing retarded fetal growth
- Cold and flu-like symptoms after ovulation, IUI or IVF transfer
- Family history of immune disorder
Immunological causes of recurrent miscarriage:
- Embryo signaling
The embryo secrets HLA G antigen to signal the mothers immune cells to allow it to grow and stay. But the improper function of the HLA G antigen improperly function and mother’s immune cells attack the embryo which leads to miscarriage. There is a testing to determine if this is happening
- Problem with mother’s immune response to the embryo
This happens when the mothers immune cells do not respond to the healthy signal of the HLA G antigen release. So the mother’s immune cells attack the embryo and it stops dividing and replicating. The embryo fails to grow and dies.
The vessels in the placenta take blood and nutrients to the fetus. In case of a Thrombophilia, or blood clotting issue related immunological miscarriage, those vessels clot off, factually starving the embryo of oxygen, blood, and nutrients. Blood testing can determine if this is the factor.
- Antisperm Antibody
In some people, semen can cause an immune response in men and women. Antibodies are triggered by the immune response that attacks sperm, thus not allowing them to fertilize the egg in the female.